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TitleEffects of cranberry juice consumption on vascular function in patients with coronary artery disease
Publication TypeJournal Article
Year of Publication2011
AuthorsDohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, Blumberg JB, Vita JA
JournalThe American Journal of Clinical Nutrition

{{{\textless}AbstractText} {Label="BACKGROUND"} {NlmCategory="BACKGROUND"{\textgreater}Cranberry} juice contains polyphenolic compounds that could improve endothelial function and reduce cardiovascular disease {risk.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="OBJECTIVE"} {NlmCategory="OBJECTIVE"{\textgreater}The} objective was to examine the effects of cranberry juice on vascular function in subjects with coronary artery {disease.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="DESIGN"} {NlmCategory="METHODS"{\textgreater}We} completed an acute pilot study with no placebo (n = 15) and a chronic placebo-controlled crossover study (n = 44) that examined the effects of cranberry juice on vascular function in subjects with coronary artery {disease.{\textless}/AbstractText{\textgreater}} {{\textless}AbstractText} {Label="RESULTS"} {NlmCategory="RESULTS"{\textgreater}In} the chronic crossover study, subjects with coronary heart disease consumed a research preparation of double-strength cranberry juice (54% juice, 835 mg total polyphenols, and 94 mg anthocyanins) or a matched placebo beverage (480 {mL/d)} for 4 wk each with a 2-wk rest period between beverages. Beverage order was randomly assigned, and participants refrained from consuming other flavonoid-containing beverages during the study. Vascular function was measured before and after each beverage, with follow-up testing ≥12 h after consumption of the last beverage. Mean {(±SD)} carotid-femoral pulse wave velocity, a measure of central aortic stiffness, decreased after cranberry juice (8.3 ± 2.3 to 7.8 ± 2.2 m/s) in contrast with an increase after placebo (8.0 ± 2.0 to 8.4 ± 2.8 m/s) {(P} = 0.003). Brachial artery flow-mediated dilation, digital pulse amplitude tonometry, blood pressure, and carotid-radial pulse wave velocity did not change. In the uncontrolled pilot study, we observed improved brachial artery flow-mediated dilation (7.7 ± 2.9% to 8.7 ± 3.1%